Endpoints News

Sensible raises $47M for mRNA therapy manufacturing platform

Unlocking mRNA Therapeutics

The world's first integrated cell-based mRNA design and manufacturing platform. Built to enable safe, effective, and accessible mRNA medicines.

In partnership with
Supported by
In partnership with
Supported by

Synthetic mRNA has reached its limits

For 40 years, mRNA has been made in a synthetic, cell-free process called in vitro transcription (IVT).

It has never been scaled to the quality or quantity required for approved therapeutics.

1985
1990
2005
2020
Now
First synthetic
mRNA is made
mRNA works in animals
Non-natural modifications decreased immunogenicity of synthetic mRNA
First clinical trial with mRNA
First mRNA medicine is approved: COVID-19 vaccine

approved mRNA therapeutics

  1. 1985

    First synthetic mRNA is made

  2. 1990

    mRNA works in animals

  3. 2005

    Non-natural modifications decreased immunogenicity of synthetic mRNA

  4. First clinical trial with mRNA

  5. 2020

    First mRNA medicine is approved: COVID-19 vaccine

  6. NOW

approved mRNA therapeutics

two inputs
Engineered cell line
Media
many inputs
Capping enzyme
T7 RNA polymerase
Nucleotides
Linearized DNA template
DNAase / RNAase inhibitors
Many more componants
many inputs
dsRNA
Residuals / metal ions
mRNA molecules
Endotoxins
RNA-DNA hybrids
Abortive RNA fragments
Uncapped mRNA
RNases
many inputs
mRNA molecules

Synthetic mRNA has fundamental limitations

01
low quality

Low quality
Synthetic mRNA contains double-stranded RNA impurities that drive unwanted immune response.

02
Immunogenicity

Constrains the therapeutic window and limits repeat dosing.

03
Fragile supply chain

Clinical-grade synthetic mRNA production depends on a handful of concentrated global suppliers of enzymes, nucleotides, and plasmid DNA.

many inputs
Capping enzyme
T7 RNA polymerase
Nucleotides
Linearized DNA template
DNAase / RNAase inhibitors
Many more componants
many outputs
dsRNA
Residuals / metal ions
mRNA molecules
Endotoxins
RNA-DNA hybrids
Abortive RNA fragments
Uncapped mRNA
RNases

Exquisitely simple and better, by its nature

01
High-quality

Our VECTOR™ platform integrates mRNA design and cell engineering to produce high-quality mRNA the way nature does

02
Purity

Cell-made mRNA is pure, immune-silent, naturally modified, and well-suited for therapeutic development.

03
All modalities

VECTOR™ is a full-stack platform supporting linear, circular, and self-amplifying RNA modalities.

TWO INPUTS
Engineered cell line
Media
pure output
mRNA molecules
Our VECTOR™ platform
1
:

DESIGN

Our AI-driven platform can generate and screen hundreds of mRNA sequence candidates in parallel, building a massive proprietary database that trains our models. Each design cycle produces better mRNA sequences, all of which generate novel composition-of-matter IP.

Learn more
2
:

ENGINEERING

We engineer proprietary producer cell lines for each therapeutic mRNA, optimized for yield, quality, and consistency.

Learn more
3
:

EXTRACTION

Our patented PromPT™ technology (Programmable mRNA Protein Transporter) selectively captures target mRNA inside the cell, packaging and protecting it from contamination before extraction. Double-stranded RNA never makes it through.

Learn more
4
:

mRNA

The result is pure, non-immunogenic, naturally modified mRNA that’s better suited for clinical development than legacy synthetic mRNA.

Learn more
Partner with Sensible

Co-developing
mRNA medicines

PARTNER WITH SENSIBLE

We bring the unique AI-driven mRNA data platform, IP, and manufacturing capabilities that take mRNA all the way from design to clinical-grade production.

We work with our partners to co-develop mRNA medicines that aren’t possible without our platform.

DESIGN
Optimization
Production

Platform partnerships

We optimize and manufacture mRNA for your therapeutic program. We license Sensible-originated sequences and strains, and support your preclinical and clinical manufacturing.
Your mRNA target
Sensible's mRNA optimization
Sensible's mRNA production

Platform partnerships

We optimize and manufacture mRNA for your therapeutic program. We license Sensible-originated sequences and strains, and support your preclinical and clinical manufacturing.
DESIGN
Your mRNA target
OPTIMIZATION
Sensible's mRNA optimization
PRODUCTION
Sensible's mRNA production

Sensible pipeline

We advance therapeutic programs to IND, with options to co-develop or out-license at clinical readout.
DESIGN
Sensible’s therapeutic sequence
OPTIMIZATION
Sensible mRNA optimization
PRODUCTION
Partner co-develops or out-licenses
Locations

Explore Sensible locations

Company

Securing the global mRNA supply chain

mRNA will be the most important molecule of the 21st century. We’re making it safe and effective enough for therapeutics, and ensuring democracies have access to the next generation of mRNA medicines.

To date, Sensible has secured up to $20 million in non-dilutive funding from NATO, the European Union, and the Slovak and German governments, with equity funding by In-Q-Tel.

Our facilities span the United Kingdom, United States, and Slovakia.

securing-the-global-mrna-supply-chain-3
Scale-Up & cGMP Manufacturing
Sarisske Michalany, Slovakia
49.07
21.14

Šarišské Michalany is focused on scale-up and cGMP manufacturing of cell-produced mRNA. The facility is designed to take processes developed across our R&D sites and translate them into larger-scale, controlled and quality-compliant production. It provides the manufacturing infrastructure needed to support clinical and commercial development as Sensible's platform progresses toward increasingly demanding applications and volumes.

process-development-optimisation
Process Development & Optimisation
Bratislava, Slovakia
48.1486
17.1077

Our Bratislava laboratories focus on translating new mRNA designs into robust, reproducible production processes. Work spans cell-line and cultivation optimisation, upstream process development, downstream purification, analytical development and optimisation of the broader production workflow. The site bridges early-stage R&D with scalable manufacturing, helping turn promising constructs into processes that can be reliably transferred toward larger-scale production.

securing-the-global-mrna-supply-chain
Discovery & Advanced R&D
Oxford, United Kingdom
51.7519
-1.2578

Our Oxford site is focused on frontier research and technology development for our cell-based mRNA platform. The team works on new sequence designs, sequence and process optimisation, high-throughput screening, data-driven and AI-assisted development, and the exploration of new attributes of cell-produced mRNA. Oxford also serves as a key hub for scientific partnerships, business development and customer-facing technical work.

Team

Leadership

Miroslav Gašpárek
Miroslav Gašpárek
Co-Founder and CEO
Marian Kupčulák
Marian Kupčulák, DPhil
Co-Founder and Chief Science Officer
Alain Pralong
Alain Pralong, PhD
Chief Technology Officer
Elena Pamětická
Vice President of Finance
Mária Nosáľová Grežďová
Mária Nosáľová Grežďová
Head of People
Katarína Doboš Chovancová
Katarína Doboš Chovancová, PhD
Head of Grants and Procurement
Updates & Insights

Latest news

Exclusive: Startup gets $47M for mRNA therapy manufacturing platform
October 5, 2026
Learn more
Ginkgo partners up with Sensible Biotechnologies to forge mRNA manufacturing platform
April 3, 2023
Learn more
Sensible Biotechnologies And Ginkgo Bioworks Announce Partnership To Make In Vivo RNA To Unlock The Promise Of RNA Therapeutics
April 3, 2023
Learn more

EU funded project

IPCEI Med4Cure — Eukarytotic mRNA (EUmRNA)

Official project title
Eukarytotic mRNA (EUmRNA) by Sensible Biotechnologies s.r.o., IPCEI Med4Cure
Project code
401103G546
About
The project focuses on the research, development and optimisation of mRNA technologies, particularly the optimisation of mRNA manufacturing and the development of analytical processes for its quality control. It forms part of the Important Project of Common European Interest IPCEI Med4Cure in the field of critical biotechnologies.
Objectives
The project aims to develop and optimise innovative mRNA technologies and processes and support their further industrialisation. The expected outcome is the introduction of a product or process innovation and the implementation of productive investments in biotechnology.
Funding
This project is implemented with financial support from the European Union under Programme Slovakia and is co-financed by the European Regional Development Fund (ERDF). Total eligible project expenditure is EUR 13,590,313.81, of which the grant amounts to EUR 11,000,000.

Our team

Alain Pralong
Alain Pralong, PhD
Chief Technology Officer
Alexandra Korobová
Alexandra Korobová
Branislav Blaško
Branislav Blaško
Dakota Wilson
Dakota Wilson
Dominika Vojtková
Dominika Vojtková
Dominika Zlatohlavá
Dominika Zlatohlavá
Elena Pamětická
Vice President of Finance
Emma Štullerová
Emma Štullerová
Erika Gyöngyösiová
Erika Gyöngyösiová
Gabriela Gnipová
Gabriela Gnipová
Jana Išová
Joe Zoeller
Clinical Researcher
José Manuel Vázquez Peña
José Manuel Vázquez Peña
Karol Kuda
Karol Kuda
Katarína Doboš Chovancová
Katarína Doboš Chovancová, PhD
Head of Grants and Procurement
Katarína Reichwalderová
Katarína Reichwalderová
Kazimir Uzwyshyn-Jones
Clinical Researcher
Kelvin Yaprianto
Kelvin Yaprianto
Krishna Motheramgari
Krishna Motheramgari
Kristína Balčoková
Kristína Balčoková
Kristína Bubláková
Kristína Bubláková
Kristína Jamborová
Kristína Jamborová
Kristína Rabská
Kristína Rabská
Liudmyla Kapustian
Liudmyla Kapustian
Mária Lacková
Mária Lacková
Marian Kupčulák
Marian Kupčulák, DPhil
Co-Founder and Chief Science Officer
Marian Kupčulák
Marian Kupčulák, DPhil
Co-Founder and Chief Science Officer
Mária Nosáľová Grežďová
Mária Nosáľová Grežďová
Head of People
Mario Simo Hernando
Mario Simo Hernando
Martina Bieliková
Martina Bieliková
Michal Karlubík
Michal Karlubík
Head of Partnerships & External Affairs
Michal Palatáš
Michal Palatáš
Miroslav Gašpárek
Miroslav Gašpárek
Co-Founder and CEO
Miroslav Gašpárek
Miroslav Gašpárek
Co-Founder and CEO
Natália Boronkajová
Natália Boronkajová
Neelam Mehta
Neelam Mehta
Patrik Cabadaj
Patrik Cabadaj
Robert Hieronymus
Robert Hieronymus
Romana Halová
Romana Halová
Roman Hrivňák
Roman Hrivňák
Stanislav Šoltys
Stanislav Šoltys
Terézia Čorňáková
Veronika Danková
Veronika Danková
Veronika Múdra
Veronika Múdra
Veronika Pavolová
Veronika Pavolová
Vikram Shaw
Clinical Researcher
Viktória Horváthová
Viktória Horváthová
Viktória Pevná
Viktória Pevná
Žaneta Semanová
Žaneta Semanová
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EU funded project

IPCEI Med4Cure — Eukarytotic mRNA (EUmRNA)

Official project title
Eukarytotic mRNA (EUmRNA) by Sensible Biotechnologies s.r.o., IPCEI Med4Cure
Project code
401103G546
About
The project focuses on the research, development and optimisation of mRNA technologies, particularly the optimisation of mRNA manufacturing and the development of analytical processes for its quality control. It forms part of the Important Project of Common European Interest IPCEI Med4Cure in the field of critical biotechnologies.
Objectives
The project aims to develop and optimise innovative mRNA technologies and processes and support their further industrialisation. The expected outcome is the introduction of a product or process innovation and the implementation of productive investments in biotechnology.
Funding
This project is implemented with financial support from the European Union under Programme Slovakia and is co-financed by the European Regional Development Fund (ERDF). Total eligible project expenditure is EUR 13,590,313.81, of which the grant amounts to EUR 11,000,000.